Some problems I've encountered. Rules as written are too constricting. Forcing characters to strictly follow 5E level based advancement. To material rewards? As in you can't get advanced cyberware unless you're the right level? As opposed to cash on hand. Also the game goes out of it's way to limit access to ammo etc. Because again, artificial restrictions. Because the 2nd level wizard can't get a machine gun too early... even they're everywhere. Because blah blah bio chip.

This is actually one of the best treatments for a nanotech post/transhuman setting I have ever read for an RPG. Don't let the anime trappings put you off. It's very smart and well thought out.